C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/7.0
C07K 7/04 (2006.01) A61K 39/00 (2006.01) C07K 14/25 (2006.01)
Patent
CA 1291035
ABSTRACT: The invention relates to a number of synthetic polypeptides which correspond to a part of the sequences of the Shiga B peptide chain. More specifically, the invention relates to polypeptides corresponding to the residues 5 to 18, 7 to 26, 13 to 26, and 19 to 29 of said B chain. The invention further relates to the conjugates of each of these with a suitable carrier and to polymers of each or these obtained by polymerization with a suitable polymerization agent: these can be used as effective vaccines which afford protection against Shiga toxin. Anti-peptide anti-sera are effective in neutralizing to a large extent the biological activity of Shiga toxin.
541391
Arnon Ruth
Donohue-Rolf Arthur
Harari Ilana
Keusch Gerald T.
Arnon Ruth
Borden Ladner Gervais Llp
Donohue-Rolf Arthur
Harari Ilana
Keusch Gerald T.
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