Shigella ipad protein and its use as a potential vaccine...

Details Shigella ipad protein and its use as a potential vaccine... Shigella ipad protein and its use as a potential vaccine...

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61P 31/04 (2006.01) C07K 14/25 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2563214

The present invention relates to a composition and a method for eliciting an immunogenic response in animals, including responses that provide protection against, or reduce the severity of shigella infections. More particularly it relates to the use of the IpaD protein obtained from natural sources and/or through synthesis or recombinant technology, and conjugates thereof to induce neutralizing antibodies having protective activity against several serotypes of Shigella, in particular S. flexneri. The composition of the invention is useful to prevent and/or treat shigellosis caused by a bacterium of the Shigella family.

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