Short interfering ribonucleic acid (sirna) for oral...

Details Short interfering ribonucleic acid (sirna) for oral... Short interfering ribonucleic acid (sirna) for oral...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/712 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2649876

Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.

L'invention concerne un acide ribonucléique interférent court (siRNA) pour administration orale, ce siRNA comprenant deux brins d'ARN séparés mutuellement complémentaires sur au moins 15 nucléotides, chaque brin comprenant 49 nucléotides ou moins, l'un au moins de ces brins présentant au moins une modification chimique.

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