Short interfering rna as an antiviral agent for hepatitis c

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2534991

Hepatitis C virus (HCV) is a major cause of chronic liver disease and affects over 270 million individuals worldwide. The HCV genome is a single-stranded RNA that functions as both a messenger RNA and replication template, making it an attractive target for the study of RNA interference. Double-stranded short interfering RNA (siRNA) molecules designed to target the HCV genome are disclosed herein.

Le virus de l'hépatite C (VHC) est une cause majeure de l'hépatite chronique et touche plus de 270 millions de personnes dans le monde. Le génome du VHC est un ARN simple brin qui fonctionne à la fois comme ARN messager et comme matrice de réplication, et constitue ainsi une cible intéressante pour l'étude de l'interférence de l'ARN. Des molécules de petit ARN interférant double brin (ARNsi) conçues pour cibler le génome de VHC sont également décrites.

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