Short interfering rna duplexes targeting an ires sequence...

Details Short interfering rna duplexes targeting an ires sequence... Short interfering rna duplexes targeting an ires sequence...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2647685

The invention provides novel inhibitory polynucleotides directed against IRES sequences. The invention also provides genetically engineered expression vectors, host cells, transgenic animals, and transgenic plants comprising the novel inhibitory polynucleotides of the invention. The invention additionally provides methods of using the inhibitory polynucleotides of the invention.

L'invention concerne de nouveaux polynucléotides inhibiteurs dirigés contre des séquences IRES. Elle concerne également des vecteurs d'expression génétiquement modifiés, des cellules hôtes, des animaux transgéniques et des plantes transgéniques comprenant les nouveaux polynucléotides inhibiteurs de l'invention. L'invention concerne en outre des procédés d'utilisation des polynucléotides inhibiteurs de l'invention.

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