Short oligonucleotides for the inhibition of vegf expression

Details Short oligonucleotides for the inhibition of vegf expression Short oligonucleotides for the inhibition of vegf expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339416

The present invention relates to a short oligonucleotide or a derivative thereof which has a sequence that corresponds to a particular part of a nucleic acid sequence which encodes VEGF (vascular endothelial growth factor) and which has a length of maximum 15 nucleotides, the invention further relates to a method of making the oligonucleotide and the use thereof. A short oligonucleotide or a derivative thereof, which has a length of 10 to 15 nucleotides and which corresponds to a part of a VEGF encoding sequence, wherein the part of the VEGF encoding sequence to which the oligonucleotide corresponds to has one of the sequences SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6 or a part thereof, wherein SEQ ID NO. 1 is 5'-CCCGGCCCCGGTCGGGCCTCCG-3', SEQ ID NO. 2 is 5'-CGGGCCTCCGAAACC- 3', SEQ ID NO. 3 is 5'-GCTCTACCTCCACCATGCCAA-3', SEQ ID NO. 4 is 5'- GTGGTCCCAGGCTGCACCCATGGC-3', SEQ ID NO. 5 is 5'-CATCTTCAAGCCATCC-3', and SEQ ID NO. 6 is 5'-TGCGGGGGCTGCTGC-3'.

L'invention concerne un oligonucléotide court, ou un dérivé de celui-ci, lequel possède une séquence correspondant à une partie spéciale d'un acide nucléique codant pour VEGF (facteur de croissance des cellules endothéliales vasculaires) et possédant une longueur maximale de 15 nucléotides; elle concerne en outre la préparation d'un tel oligonucléotide et l'utilisation de celui-ci. Cet oligonucléotide court ou un dérivé de celui-ci possède une longueur de 10 à 15 nucléotides et correspond à une partie de la séquence codant pour VEGF, la partie de cette séquence à laquelle l'oligonucléotide correspond possède l'une des séquence suivantes (SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3, SEQ ID NO.4, SEQ ID NO.5 ou SEQ ID NO6), ou une partie de celle-ci: SEQ ID NO.1 représentant 5'-CCCGGCCCCGGTCGGGCCTCCG-3' SEQ ID NO.2 représentant 5'-CGGGCCTCCGAAACC-3' SEQ ID NO.3 représentant 5'-GCTCTACCTCCACCATGCCAA-3' SEQ ID NO.4 représentant 5'-GTGGTCCCAGGCTGCACCCATGGC-3' SEQ ID NO.5 représentant 5'-CATCTTCAAGCCATCC-3' et SEQ ID NO.6 représentant 5'-TGCGGGGGCTGCTGC-3'.

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