Short rna antagonist compounds for the modulation of hif1alpha

Details Short rna antagonist compounds for the modulation of hif1alpha Short rna antagonist compounds for the modulation of hif1alpha

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2701895

The present invention relates to oligomer compounds (oligorners) of 12, 13 or 14 nucleotides in length, which target Hif1 alpha mRNA in a cell, leading to reduced expression of Hif1 alpha. Reduction of Hif 1 alpha expression is beneficial for the treatment of certain medical disorders, such as hyperproliferative disorders, such as cancer.

L'invention concerne des composés oligomériques (oligomères) d'une longueur de 12, 13 ou 14 nucléotides, qui ciblent l'ARNm d'Hif1 alpha dans une cellule, entraînant une expression réduite d'Hif1 alpha. La réduction de l'expression d'Hif1 alpha s'avère bénéfique dans le traitement de certaines affections médicales, comme les troubles hyperprolifératifs tels que le cancer.

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