C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 35/18 (2006.01) A61K 38/20 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2111564
2111564 9300918 PCTABS00019 The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo) as represented by a decrease in the number of tumors by at least about 20 %.
Loeffler Cynthia
Longo Dan L.
Ochoa Augusto C.
Urba Walter
Loeffler Cynthia
Longo Dan L.
Ochoa Augusto C.
Smart & Biggar
Urba Walter
LandOfFree
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