Sialic acid derivatives for use as siglec inhibitors

Details Sialic acid derivatives for use as siglec inhibitors Sialic acid derivatives for use as siglec inhibitors

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 31/7012 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C07H 7/027 (2006.01)

Patent

CA 2451051

the invention relates to Siglec inhibitors that have an increased affinity for the receptor molecule. The Siglec inhibitors provided by the invention are preferably selective of a given Siglec molecule. The invention further relates to method for producing Siglec inhibitors and to a method for increasing the binding selectivity for a given Siglec molecule. The invention also relates to pharmaceutical compositions that contain the Siglec inhibitors and to medical indications for the Siglec inhibitors.

L'invention concerne des inhibiteurs de Siglec présentant une affinité accrue pour la molécule réceptrice. De préférence, ces inhibiteurs de Siglec agissent de manière sélective sur une molécule de Siglec donnée. L'invention concerne en outre des procédés pour produire des inhibiteurs de Siglec et des procédés pour accroître la sélectivité de liaison pour une molécule de Siglec donnée. L'invention concerne également des compositions pharmaceutiques contenant ces inhibiteurs de Siglec. Des indications médicales des inhibiteurs de Siglec sont également décrites.

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