C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/36 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 15/75 (2006.01)
Patent
CA 2578050
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
L'invention concerne de nouvelles compositions ainsi que de nouveaux procédés de prévention et de traitement de l'infection pathogène. En particulier, l'invention concerne des composés qui comportent des domaines d'ancrage qui fixe le composé à la surface d'une cellule cible, ainsi qu'un domaine thérapeutique qui peut agir de manière extracellulaire pour empêcher l'infection d'une cellule cible par un agent pathogène, tel qu'un virus. De plus, l'invention concerne des compositions thérapeutiques à activité sialidase, qui renferment des composés protéiques pourvus de domaines catalytiques sialidase. Les composés de l'invention peuvent servir à traiter ou prévenir l'infection pathogène, et à traiter et réduire les réponses allergiques et inflammatoires. Par ailleurs, l'invention concerne des compositions et des procédés qui favorisent la transduction des cellules cibles par les virus recombinés. Ses compositions et procédés peuvent être utilisés en thérapie génique.
Fang Fang
Malakhov Michael
Borden Ladner Gervais Llp
Fang Fang
Malakhov Michael
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