Sialyl lex analogues as inhibitors of cellular adhesion

Details Sialyl lex analogues as inhibitors of cellular adhesion Sialyl lex analogues as inhibitors of cellular adhesion

C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) A61K 31/70 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C07H 7/02 (2006.01) C07H 13/08 (2006.01) C07H 13/10 (2006.01) C07H 15/04 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2162478

The present invention relates to analogues of Sialyl Lewisx that inhibit cellular adhesion between a selectin receptor and cells that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compounds and their intermediates. A contemplated or inhibitor compound has the 2-N-acetyl moiety of the GlcNAc with YR1 wherein Y is C(O), SO2, HNC(O) or SC(O) and R1 is aryl, substituted aryl, or phenyl C1-C3 alkylene moieties.

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