C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/02 (2006.01) A61K 45/00 (2006.01) A61P 31/04 (2006.01) C12N 9/00 (2006.01)
Patent
CA 2734734
The present invention relates to methods of inhibiting S. aureus comprising inhibiting siderophore-mediated iron uptake, for example, staphyloferrm-mediated iron uptake Such methods of inhibiting S. aureus include the inhibition of staphylo-ferrm A- and staphyloferrm B- mediated uptake either by inhibiting expression or activity of staphyloferrm A and B or by inhibit-ing transport of staphyloferrm A and B The methods as provided would be useful for treating S. aureus infection
La présente invention concerne des procédés dinhibition de S. aureus comprenant linhibition dabsorption du fer par lintermédiaire de sidérophore, par exemple, labsorption du fer par lintermédiaire de staphyloferrm. De tels procédés dinhibition de S. aureus comprennent linhibition par lintermédiaire de staphyloferrm A et staphyloferrm B soit par linhibition de lexpression ou de lactivité de staphyloferrm A et B soit par linhibition de transport de staphyloferrm A et B. Les procédés selon linvention sont utiles pour le traitement dinfection par S. aureus.
Beasley Federico
Cheung Johnson
Heinrichs David E.
Vines Enrique
Gowling Lafleur Henderson Llp
The University Of Western Ontario
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