Sigma-2 receptors as biomarkers of tumor cell proliferation

Details Sigma-2 receptors as biomarkers of tumor cell proliferation Sigma-2 receptors as biomarkers of tumor cell proliferation

C - Chemistry, Metallurgy

07

D

C07D 451/04 (2006.01) A61K 31/44 (2006.01) A61K 31/46 (2006.01) A61K 51/04 (2006.01) C07D 451/06 (2006.01) C07D 451/14 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2249410

Detectably-labeled compounds of formula (I) wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of Q 2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).

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