C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2447332
It is intended to provide a method of amplifying DNA chip signals whereby the signal amplification of a target gene captured on a DNA chip is efficiently established by using the PALSAR method and easily detected by adequately designing a pair of HCPs to be used in the PALSAR method. Namely, the sensitivity of detecting a target gene in a DNA chip is improved with the use of a self-aggregation reaction of forming a self-aggregate which is a regular higher-order structure of the double strands of an oligonucleotide.
L'invention concerne un procédé d'amplification des signaux de puces ADN. Un procédé PALSAR permet d'amplifier efficacement les signaux d'un gène cible capturé sur une puce ADN et de détecter facilement ce dernier en formant une paire de sondes HCP appropriée pour le procédé PALSAR. On améliore en outre la sensibilité de détection d'un gène cible dans une puce ADN en faisant intervenir une réaction d'auto-agrégation favorisant la production d'un auto-agégrat sous la forme d'une structure d'ordre supérieure des doubles brins d'un oligonucléotide.
Hakii Chikako
Mitsuka Mari
Usui Mitsugu
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sanko Junyaku Co. Ltd.
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