Signal peptide, dna sequences coding for the latter,...

C - Chemistry – Metallurgy – 12 – N

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195/1.22, 195/1.

C12N 15/67 (2006.01) C07K 14/61 (2006.01) C07K 14/815 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01)

Patent

CA 1334944

The invention relates to a signal peptide of the formula : MXKSTLLLLFLLLCLPSWNAGA in which: A = Alanine M = Methionine C = Cysteine N = Asparagine F = Phenylalanine P = Proline G = Glycine S = Serine K = Lysine T = Threonine L = Leucine W = Tryptophan and X represents a direct bond between M and K, an amino acid selected from the group comprising the 20 amino acids of the genetic code, or a peptide containing 2, 3 or 4 amino acids selected, each independently of the other, from the group comprising the 20 amino acids of the genetic code. Application : Use for the periplasmic production of polypeptides.

609139

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