Signal peptide for the excretion of peptides in streptomycetes

Details Signal peptide for the excretion of peptides in streptomycetes Signal peptide for the excretion of peptides in streptomycetes

C - Chemistry, Metallurgy

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530/7.08, 195/1.

C12P 21/02 (2006.01) C07K 7/08 (2006.01) C07K 14/36 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/76 (2006.01) C12P 19/34 (2006.01)

Patent

CA 1309674

Abstract of the Disclosure: A prepeptide comprising 20 to 35 amino acids, of the formula Met-Arg-Val-Arg-Ala-Leu-Arg-X-Ala-Ser-Ala (I) in which X represents a hydrophobic region of 10 to 25 amino acids, acts in Streptomycetes as a signal peptide which removes from the cell a peptide which is linked to it via its amino terminal end, and excretes it into the culture medium. A corresponding gene structure can be incorporated upstream of a structural gene, and then on expression brings about the excretion of the desired peptide into the culture medium. For this purpose, suit- able plasmids are modified by incorporation of genes of this type, and host organisms, in particular Strepto- mycetes, are transformed with them.

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