A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/46 (2006.01) A61K 9/70 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2417736
Solid dispersions of sildenafil citrate and certain highly water soluble sugars are provided, which solid dispersions significantly increase the water solubility of sildenafil citrate. Methods for preparing highly water soluble solid dispersions of the present invention facilitate the incorporation of sildenafil citrate into new sildenafil citrate containing dosage forms which were heretofore impractical. A method for improving and/or enhancing the sexual response in animals, particularly humans, by administering such new sildenafil citrate containing dosage forms is also provided.
Cette invention se rapporte à des dispersions solides de citrate de sildénafil et à certains sucres fortement hydrosolubles, ces dispersions solides accroissant considérablement la solubilité dans l'eau du citrate de sildénafil et sa biodisponibilité. Cette invention concerne des procédés pour préparer des dispersions solides de citrate de sildénafil fortement hydrosolubles. Ces dispersions solides facilitent l'incorporation du citrate de sildénafil dans de nouvelles formes posologiques contenant du citrate de sildénafil, ce qui était jusqu'à présent impossible à mettre en pratique. Un procédé pour améliorer et/ou stimuler les réactions sexuelles chez les animaux, en particulier chez l'homme en administrant ces nouvelles formes posologiques contenant du citrate de sildénafil est également décrit.
Chen Li-Lan
Tao Li
Lavipharm Laboratories Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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