Silenced anti-cd28 antibodies and use thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2432736

The present invention provides anti-CD28 antibodies which are defective in mitogenic activity (silenced anti-CD28 antibodies), methods of producing, compositions containing the antibody and methods of immunosuppression, inducing T-cell tolerance and treating organ and/or tissue transplant rejections.

L'invention concerne des anticorps anti-CD28 défectueux en activité mitogène (anticorps anti-CD28 silencieux), leurs procédés de fabrication, des compositions contenant l'anticorps et des procédés d'immunosuppression, induisant la tolérance de cellules T et traitant de rejets de greffes d'organes et/ou de tissus.

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