Silk polymer-based adenosine release: therapeutic potential...

A - Human Necessities – 61 – K

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Details

A61K 47/42 (2006.01) A61K 9/00 (2006.01) A61K 31/7076 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2721961

This invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine, that provide for sustained, focal release of adenosine at therapeutic levels for the treatment of epilepsy and/or the prevention of epileptogenesis. An embodiment provides for a silk-based, adeno sine-releasing implant that alleviates seizures or prevents epileptogen-esis. Another embodiment provides for a method of treating epilepsy or preventing epileptogenesis comprising focally administer-ing adenosine in a sustained-release, silk-based adenosine delivery system.

Cette invention concerne des formulations à libération prolongée qui renferment un biopolymère de fibroïne de soie et de l'adénosine, et qui permettent une libération focale prolongée d'adénosine à des niveaux thérapeutiques pour le traitement de l'épilepsie et/ou la prévention d'une épileptogenèse. Un mode de réalisation concerne un implant de libération d'adénosine à base de soie qui soulage les crises ou prévient une épileptogenèse. Un autre mode de réalisation concerne un procédé pour traiter l'épilepsie ou prévenir une épileptogenèse, qui consiste à administrer de manière focale de l'adénosine dans un système dadministration d'adénosine à base de soie, à libération prolongée.

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