Silver-containing, sol-gel derived bioglass compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61L 17/00 (2006.01) A61L 27/10 (2006.01) A61L 27/30 (2006.01) A61L 27/54 (2006.01) C03C 3/078 (2006.01) C03C 3/097 (2006.01) C03C 4/00 (2006.01) C03C 8/08 (2006.01) C03C 13/00 (2006.01) C03C 14/00 (2006.01)

Patent

CA 2377402

Silver-containing, sol-gel derived bioactive glass compositions and methods of preparation and use thereof are disclosed. The compositions can be in the form of particles, fibers and/or coatings, among other possible forms, and can be used, for example, for treating wounds, improving the success of skin grafts, reducing the inflammatory response and providing anti-bacterial treatments to a patient in need thereof. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating the compositions into or onto the implanted materials. The compositions can also be used to prepare devices used for <i>in vitro</i> and <i>ex vivo</i> cell culture.

L'invention concerne des compositions de verre bioactif contenant de l'argent et obtenu par une technique sol-gel, ainsi que leurs procédés de préparation et d'utilisation. Les compositions peuvent se présenter, entre autres, sous forme de particules, de fibres et/ou d'enrobages, et peuvent être utilisées, par exemple, dans le traitement des blessures, le perfectionnement des greffes cutanées, la réduction de la réponse inflammatoire et la préparation de traitements anti-bactériens pour les patients en ayant besoin. Les propriétés anti-bactériennes peuvent être transmises à des matières implantées telles qu'implants prothétiques, sutures, moulages, vis, plaques, tubes, etc., par incorporation des compositions dans ou sur les matières implantées. Les compositions peuvent également être utilisées dans la préparation de dispositifs utilisés dans la culture cellulaire (<i>in vitro</i>) (<i>ex vivo</i>).

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