Silylated piperidine derivatives

Details Silylated piperidine derivatives Silylated piperidine derivatives

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) A61K 31/695 (2006.01)

Patent

CA 2672574

Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of Aß(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.

L'invention porte sur des composés représentés par la formule I : I dans laquelle au moins l'un de R4 et R5 comprend Si (R6)3 comme substituant. Ces composés atténuent de manière sélective la production de Aß(1-42) et, par conséquent, trouvent une utilisation dans le traitement de la maladie d'Alzheimer et des états apparentés.

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