Silylmethyl-aniline derivatives, methods of preparation and...

Details Silylmethyl-aniline derivatives, methods of preparation and... Silylmethyl-aniline derivatives, methods of preparation and...

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) A61K 31/695 (2006.01) C07F 7/08 (2006.01)

Patent

CA 2194677

Aromatic silyl-methylamine derivatives of general formula (I), in which R1 is a hydrogen atom, a variously substituted aromatic residue, an alkyl residue and/or functional groups, R2 and R3 are an aromatic residue, a hydrogencarbon radical, Ar1 and Ar2, which are the same or different, are an aryl grouping, in particular (a) and (b) wherein R4, R5, R6 and R7 are a hydrogen atom, an aromatic residue, an alkyl radical and/or various functions. The invention also concerns a process for the preparation of these derivatives by condensation of an aromatic amine on a silylated derivative.

La présente invention concerne des dérivés de silyl-méthylamines aromatiques de formule générale (I), dans laquelle: R1 représente un atome d'hydrogène, un résidu aromatique diversement substitué, un résidu alkyle et/ou des groupes fonctionnels, R2 et R3 représentent un résidu aromatique, un radical hydrogénocarboné, Ar1 et Ar2, identiques ou différents, représentent un groupement aryle, notamment (a) et (b) dans lesquels R4, R5, R6 et R7 représentent un atome d'hydrogène, un résidu aromatique, un radical alkyle et/ou diverses fonctions. L'invention concerne également le procédé de préparation desdits dérivés par condensation d'une amine aromatique sur un dérivé silylé.

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