A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 8/68 (2006.01) A61K 8/92 (2006.01) A61Q 19/10 (2006.01)
Patent
CA 2595023
A composition and a method of producing a composition which simulates hydration, cleansing and other properties of native vernix. The composition contains hydratable water-in-oil emulsified particles providing water vapor transport and evaporative water loss properties, rheologic, tactile, cleansing, and other properties simulating native vernix. The inventive composition simulates hydrophobic properties of native vernix by a matrix of one or more lipids that are present in native vernix, in which the simulated cells are dispersed. In one embodiment, the lipids are substantially physiologic. Any or all the following lipids may be used, each of which is found in native vernix, and each of which is available commercially : cholesterol esters, ceramides, triglycerides, cholesterol, free fatty acids, phospholipids, wax esters, squalene, wax diesters, and cholesterol sulfate. Other physiologically acceptable lipids, such Petrolatum and/or mineral oil, may be included in some formulations.
L~invention concerne une composition et un procédé de production d~une composition qui simule l'hydratation, le nettoyage et d'autres propriétés du vernix caseosa. La composition contient des particules hydratables dans une émulsion d~huile dans l~eau fournissant un transport par la vapeur d'eau et des propriétés d~évapotranspiration, des propriétés rhéologiques, tactiles, de nettoyage, ainsi que d~autres propriétés simulant le vernix caseosa. La composition de l~invention simule les propriétés hydrophobes du vernix caseosa par une matrice d'un ou plusieurs lipides présents dans le vernix caseosa, dans laquelle sont dispersées les cellules simulées. Dans un mode de réalisation, les lipides sont sensiblement physiologiques. Certains ou tous les lipides suivants peuvent être utilisés, chacun d~entre eux se trouvant dans le vernix caseosa, et chacun d~entre eux étant disponible commercialement : esters de cholestérol, céramides, triglycérides, cholestérol, acides gras libres, phospholipides, esters cireux, squalène, diesters cireux et sulfate de cholestérol. D'autres lipides acceptables sur le plan physiologique, tels que la vaseline et/ou une huile minérale, peuvent être inclus dans certaines formulations.
Hoath Steven B.
Pickens William L.
Tansirikongkol Anyarporn
Visscher Martha O.
Wickett Richard Randall
Children's Hospital & Medical Center
Macrae & Co.
University Of Cincinnati
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