C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/10 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2285384
This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.
La présente invention concerne un procédé rapide et pratique de recueil simultané d'informations génomiques et diagnostiques à partir d'un unique prélèvement sur un tampon absorbant. On a constaté, c'est l'objet de l'invention, qu'un dosage par ACP du contenu du tampon absorbant, donne des résultats aussi fiables, aussi précis et aussi sensibles que les meilleurs dosages sur base sérique disponibles (sang). Les dosages de l'invention conviennent pour confirmer entre elles, d'une part, soit la détection d'informations génomiques aboutissant à des informations de diagnostics, soit la détection, dans les informations génomiques, d'une prédisposition à une affection, et d'autre part une confirmation de la présence de l'affection par un test de diagnostic.
Bestwick Richard K.
Goldstein Andrew S.
Epitope Inc.
Fetherstonhaugh & Co.
Orasure Technologies Inc.
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