Single chain antibody library design

Details Single chain antibody library design Single chain antibody library design

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C40B 30/00 (2006.01) C40B 40/08 (2006.01) C40B 50/06 (2006.01) C40B 80/00 (2006.01)

Patent

CA 2737351

The invention provides polynucleotide vectors and linkers and methods for designing and making single chain variable fragment ("ScFv") libraries. The invention also provides polynucleotide vectors and linkers and methods for reformatting the ScFv library into Fab and IgG formats for high throughput production and screening.

Cette invention concerne des vecteurs polynucléotidiques et des lieurs ainsi que des procédés pour concevoir et préparer des banques de fragments variables du type simple chaîne « ScFv »). L'invention concerne également des vecteurs polynucléotidiques et des lieurs ainsi que des procédés pour reformater la banque ScFv sous des formats Fab et IgG pour une production et un criblage à haut débit.

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