Single chain insulin with high bioactivity

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/17 (2006.01) A61K 35/12 (2006.01) A61K 38/28 (2006.01) C07K 14/62 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2223272

The instant invention provides polypeptide compounds of the formula b-BP-a having significant insulin activity, nucleotide sequences encoding said polypeptides, vectors comprising said nucleotide sequences, and cell lines transformed with said vectors useful for treating diabetes.

Composés polypeptidiques de formule b-BP-a dotés d'une activité importante de type insuline, séquences de nucléotides codant lesdits polypeptides, vecteurs comportant lesdites séquences de nucléotides et lignées cellulaires transformées à l'aide desdits vecteurs, utiles pour traiter le diabète.

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