Single-chain polypeptides comprising troponin i and troponin c

Details Single-chain polypeptides comprising troponin i and troponin c Single-chain polypeptides comprising troponin i and troponin c

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2315282

This invention relates to single-chain polypeptides and their genetic sequences comprising human cardiac troponin I and troponin C. The single-chain polypeptide may be expressed recombinantly, and a linker peptide may be interposed between the troponin sequences. A linker peptide of about 6 to about 30 amino acids is preferred. The single chain polypeptide has utility as a control or calibrator for troponin assays, for the purification of troponin subunits and as an antigen for the preparation of antibodies.

Cette invention se rapporte aux polypeptides à chaîne unique et à leurs séquences génétiques comprenant la troponine I et la troponine C humaines cardiaques. Le polypeptide à chaîne unique peut être exprimé de manière recombinante, et un peptide lieur peut être introduit entre les séquences de troponine. De préférence, le peptide lieur contient de 6 à 30 acides aminés. Le polypeptide à chaîne unique est utile comme contrôle ou comme étalon pour les dosages de troponine, pour la purification de sous-unités de la troponine et comme antigène pour la préparation d'anticorps.

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