A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2583417
The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
L'invention concerne des méthodes destinées à traiter des maladies inflammatoires (par ex., des maladies inflammatoires chroniques) et consistant à administrer un antagoniste du récepteur 1 du facteur onconécrosant. L'invention se rapporte en outre à des ligands contenant un monomère à domaine variable unique (anticorps à domaine, dAb) d'immunoglobuline se liant au récepteur 1 du facteur onconécrosant, ainsi que des méthodes d'utilisation de ces ligands. L'invention concerne également des acides nucléiques codant pour ces ligands, des cellules hôtes recombinantes et des procédés de préparation de ces ligands.
Basran Amrik
Blein Stanislas Charles
Brewis Neil D.
Enever Carolyn
Holmes Steve
Domantis Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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