C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) C12N 9/64 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2720013
The present invention relates to single domain antibodies with a specificity for BACE1. More specifically, the invention provides single variable domain antibodies derived from camelids which bind to BACE1 and are capable of inhibiting the activity of BACE1. Said antibodies can be used for research and medical applications. Specific applications include the use of BACE1 specific antibodies for the treatment of Alzheimer's disease.
La présente invention porte sur des anticorps à domaine unique avec une spécificité pour la BACE1. Plus spécifiquement, l'invention porte sur des anticorps à domaine variable unique issus de camélides qui se lient à la BACE1 et sont capables d'inhiber l'activité de la BACE1. Lesdits anticorps peuvent être utilisés pour des applications de recherche et médicales. Des applications spécifiques comprennent l'utilisation d'anticorps spécifiques de la BACE1 pour le traitement de la maladie d'Alzheimer.
de Strooper Bart
Marjaux Els
Muyldermans Serge
Zhou Lujia
Fetherstonhaugh & Co.
Katholieke Universiteit Leuven K.u.leuven R&d
Vib Vzw
Vrije Universiteit Brussel
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