Single domain antibodies directed against tumour necrosis...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 37/06 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2505316

The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Tumor Necrosis Factor-alpha. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides.

La présente invention a trait à des polypeptides dérivés d'anticorps à domaine unique à chaînes lourdes dirigés contre le facteur de nécrose tumorale alpha. L'invention a également trait à des anticorps à domaine unique qui sont des anticorps à chaînes lourdes dépourvus de chaînes légères de l'espèce Camelidae. L'invention a trait en outre à des procédés d'administration desdits polypeptides. Enfin, l'invention a trait à des protocoles pour le criblage pour des agents de modulation du récepteur du facteur de nécrose tumorale alpha, et des agents obtenus par ledit criblage.

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