Single-domain antigen-binding proteins that bind mammalian igg

Details Single-domain antigen-binding proteins that bind mammalian igg Single-domain antigen-binding proteins that bind mammalian igg

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01)

Patent

CA 2694737

The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.

La présente invention concerne des protéines de liaison à un antigène qui sont capables de se lier à un IgG de mammifère. Les régions de cadre des protéines de liaison d'antigène de l'invention correspondent, de préférence, à celles d'anticorps qui sont naturellement dépourvus de chaînes légères telles que dans les camélides, par exemple. L'invention porte également sur des acides nucléiques qui codent pour de telles protéines de liaison d'antigène, sur des matières immunoadsorbantes qui comportent de telles protéines, sur les utilisations de ces matières immunoadsorbantes pour la purification d'anticorps d'IgG de mammifère et pour l'aphérèse thérapeutique.

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