Single-labeled oligonucleotide probes

Details Single-labeled oligonucleotide probes Single-labeled oligonucleotide probes

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2417986

Probes and methods are provided for detection and analysis of nucleic acid sequences. The probes are single-labeled oligonucleotide probes whose fluorescence emission changes in response to probe-target hybridization and dissociation. The methods are for analyzing one or multiple nucleic acid loci using the probes. This invention further relates to the use of fluorescence changes in single-labeled probes for melting curve analysis, genotyping, and pathogen detection, and to methods for quantification of specific sequences in real-time monitoring of nucleic acid amplification.

L'invention concerne des sondes et procédés de détection et d'analyse de séquences d'acides nucléiques. Ces sondes sont des sondes oligonucléotidiques simples, marquées, dont l'émission de fluorescence change en réponse à une hybridation sonde/cible et à une dissociation sonde/cible. Ces procédés sont conçus pour analyser un ou plusieurs sites d'acides nucléiques, à l'aide des sondes. L'invention concerne encore l'utilisation des changements de fluorescence dans des sondes simples marquées, aux fins d'analyse de courbes de fusion, de génotypage, et de détection de pathogènes, ainsi que des procédés de quantification de séquences spécifiques dans la surveillance en temps réel d'amplification d'acides nucléiques.

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