Single morphic forms of known peptide metalloproteinase...

Details Single morphic forms of known peptide metalloproteinase... Single morphic forms of known peptide metalloproteinase...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2347911

A single morphic form of a compound selected from 2S- [4- (2, 5 - dioxopyrrolidin- 1-yl)- 2S- mercaptobutyrylamino] -4- methylpentanoic acid (2,2- dimethyl- 1S- methylcarbamoylpropyl) amide and 2S- [2$I(S)mercapto- 4- (3, 4, 4- trimethyl- 2, 5- dioxoimidazolidin- 1-yl) butyrylamino] -4- methylpentanoic acid (2, 2-dimethyl -1S- methylcarbamoylpropyl) amide, isolable as such.

L'invention porte sur une forme morphique unique d'un composé sélectionné parmi l'acide 2S-[4-(2,5-dioxopyrrolidin-1-yl)-2S-mercaptobutyrylamino]-4-methylphentanoïque (2,2-dimethyl-1S-methylcarbamoylpropyl)amide et l'acide 2S-mercapto-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butyrylamino]-4-methylpentanoïque (2,2-dimethyl-1S-methylcarbamoylpropyl)amide pouvant être ainsi isolé.

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