Single phase gels for the prevention of adhesions

Details Single phase gels for the prevention of adhesions Single phase gels for the prevention of adhesions

C - Chemistry, Metallurgy

08

B

C08B 37/08 (2006.01) A61K 47/36 (2006.01) A61L 31/04 (2006.01) A61L 31/06 (2006.01) C08B 11/20 (2006.01) C08B 15/00 (2006.01) C08B 31/00 (2006.01) C08B 37/00 (2006.01) C08J 3/075 (2006.01) C08J 3/24 (2006.01)

Patent

CA 2398935

Single phase gels for preventing the formation of surgical adhesions are disclosed. The gels are prepared by reacting an aqueous solution of a polyanionic polysaccharide, such as hyaluronic acid or carboxymethyl cellulose, with divinyl sulfone, to form a gel, the solution is neutralized, and a solid is precipitated from the solution. The solid can be redissolved in water to form a gel having properties which can be modified to suit a particular application.

L'invention concerne des gels à phase unique permettant de prévenir la formation d'adhérences chirurgicales. Ces gels sont préparés par réaction d'une solution aqueuse de polysaccharide polyanionique, tel qu'un acide hyaluronique ou une cellulose de carbométhyle, avec un divinyl-sulfone, de façon à former un gel, la solution étant neutralisée, et un solide précipitant à partir de ladite solution. Ledit solide peut être à nouveau dissous dans l'eau de façon à former un gel possédant des propriétés pouvant être modifiées pour une application particulière.

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