Single-phase pharmaceutical composite preparation (dienogest...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/569 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2681021

The invention relates to single-phase oral contraceptives comprising a combination of 2.0 mg dienogest of the non-aldosterone antagonist type and 0.030 mg ethinyl estradiol or 2.0 mg dienogest and 0.020 mg ethinyl estradiol or 2.0 mg dienogest and 0.015 mg ethinyl estradiol or 1.5 mg dienogest and 0.015 mg ethinyl estradiol in at least (21) daily dosage units. Said oral contraceptives achieve a regulation of blood pressure - reducing elevated blood pressure and increasing depressed blood pressure - during contraception. Said oral contraceptives are particularly suitable for long-term contraceptive use without the risk of negative influence on blood pressure.

L'invention concerne des contraceptifs oraux monophasiques qui contiennent une combinaison de 2.0 mg de diénogest du type non-antagoniste de l'aldostérone et de 0.030 mg d'éthinylestradiol, de 2.0 mg de diénogest et de 0.020 mg d'éthinylestradiol, de 2.0 mg de diénogest et de 0.015 mg d'éthinylestradiol ou de 1.5 mg de diénogest et de 0.015 mg d'éthinylestradiol en au moins 21 unités correspondant à la dose quotidienne. Ces contraceptifs permettent une régulation de la pression artérielle - abaissement d'une hypertension, augmentation d'une hypotension - pendant la contraception. Ils conviennent en particulier à une utilisation contraceptive de longue durée sans risque d'influence négative sur la pression artérielle.

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