G - Physics – 01 – N
Patent
G - Physics
01
N
73/57
G01N 21/84 (2006.01) G01N 21/25 (2006.01)
Patent
CA 1305334
ABSTRACT OF THE DISCLOSURE A multibeam photometric measuring device includes a light assembly comprising a single modulated light source along with a filter assembly for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A plurality of light transmitting means accept light the focused through an efficient light distribution arrangement and transmit it individually to each of the plurality of sites disposed on a multi-well sample plate. A fiber rotor arrangement is provided for sequentially connecting the collimated light source to each of the plurality of fibers disposed in the distributor. Light passing through the wells of the sample plate is captured by discrete photodetector cells disposed on a one- to-one correspondence opposite the wells of the plate. A reference fiber links light from the light source to a separate photodetector to provide a reference light signal with which the sensed photodetector signals are compared. The sensed signals are suitably multiplexed and processed by special circuitry which allows control over the accuracy with which the signals are processed on the basis of their instantaneous strengths as well as reference readings taken during system initialization. Enhancement of color distribution resulting from chromogenic reactions is provided by automatic agitation of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.
519310
Chow Calvin Y.h.
Humphries Gillian M.
Kung Viola T.
Lacy Michael M.
Parce John Wallace
Fetherstonhaugh & Co.
Molecular Devices Corporation
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