Single-stranded antimicrobial oligonucleotides and uses thereof

Details Single-stranded antimicrobial oligonucleotides and uses thereof Single-stranded antimicrobial oligonucleotides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01)

Patent

CA 2582814

The current invention is directed to oligonucleotide sequences isolated from a sequence designated rbl-1 [SEQ ID NO. 19] that either kill or inhibit growth, or prevent the production of endogenously expressed toxin, of microorganisms. These ssDNA sequences, identified through use of a screening method, appear to act as modulators of essential growth functions which may act at the level of triplex formation, antisense inhibition, or as aptamers that alter gene function. The sequences, referred to as minimum functional regions, or MFRs, are useful inter alia as therapeutic agents for treatment of sepsis and other pathologies caused by microorganisms such as sepsis and/or in which microorganisms are contributory agents.

La présente invention concerne des séquences oligonucléotidiques isolées à partir d'une séquence appelée rbl-1 [SEQ ID NO. 19] qui soit tue soit inhibe la croissance de micro-organismes ou empêche la production d'une toxine exprimée par voie endogène. Ces séquences d'ADN monocaténaire, identifiées par utilisation d'un procédé de criblage, apparaissent comme faisant office de modulateurs de fonctions essentielles de croissance pouvant agir au niveau de la formation de triplex, de l'inhibition antisens ou d'aptamères modifiant la fonction de gènes. Les séquences, appelées régions fonctionnelles minimales ou MFR, sont utiles <i>inter alia</i> comme agents thérapeutiques de traitement de la sepsie et d'autres pathologies provoquées par des micro-organismes telles que la sepsie et/ou dans lesquels les micro-organismes sont des agents contributeurs.

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