Single-stranded, circular oligonucleotides

Details Single-stranded, circular oligonucleotides Single-stranded, circular oligonucleotides

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105864

2105864 9217484 PCTABS00016 The present invention provides single-stranded circular oligonucleotides each with a parallel binding (P) domain and an anti-parallel binding (AP) domain separated from each other by loop domains. Each P and AP domain has sufficient complementarity to bind to one strand of a defined nucleic acid target wherein the P domain binds in a parallel manner to the target and the AP domain binds in an anti-parallel manner to the target. Moreover, the present single-stranded circular oligonucleotides can bind to both single-stranded and double-stranded target nucleic acids. The present invention also provides methods of using these oligonucleotides as well as pharmaceutical compositions containing these oligonucleotides.

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