C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2383003
The invention concerns single stranded oligonucleotides comprising a sequence of at least 12 consecutive nucleotide motifs contained in one of the sequences SEQ ID N?o¿ 1 to SEQ ID N?o¿ 4 wherein "N" represents an identical or different nucleotide selected among inosine or an equimolar mixture of 4 different nucleotides selected among A, T, C or G, and among the oligonucleotides complementary of said oligonucleotides. The invention also concerns the uses of said oligonucleotides for detecting bacteria of the Spirochaeta family. The invention is based on the use of specifically defined sequences in the rpoB gene of spirochetes coding for the beta subunit of the bacterial RNA polymerase.
L'invention concerne des oligonucléotides monocaténaires choisis parmi les oligonucléotides comprenant une séquence d'au moins 12 motifs nucléotidiques consécutifs incluse dans l'une des séquences SEQ ID N~1 à SEQ ID N~4 dans lesquelles "N" représente un nucléotide identique ou différent choisi parmi l'inosine ou un mélange équimolaire de 4 nucléotides différents choisis parmi A, T, C ou G, et parmi les oligonucléotides complémentaires de ces oligonucléotides, et les applications de ces oligonucléotides pour détecter des bactéries de famille des spirochètes. L'invention repose sur l'utilisation de séquences spécifiquement définies dans le gène rpoB des spirochètes codant pour la sous-unité beta de l'ARN polymérase bactérienne.
Drancourt Michel
Raoult Didier
Goudreau Gage Dubuc
Universite de La Mediterranee (aix-Marseille Ii)
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