Sinus delivery of sustained release therapeutics

Details Sinus delivery of sustained release therapeutics Sinus delivery of sustained release therapeutics

A - Human Necessities

61

L

A61L 27/40 (2006.01) A61F 2/00 (2006.01) A61K 9/00 (2006.01) A61L 27/44 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2518960

The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

L'invention concerne des implants biodégradables permettant de traiter la sinusite. Les implants biodégradables présentent des dimensions, une forme, une densité, une viscosité et/ou une adhésivité aux muqueuses empêchant ceux-ci d'être sensiblement éliminés par le revêtement mucociliaire des sinus pendant la période de traitement. Les implants biodégradables comprennent des agents thérapeutiques à libération prolongée, par exemple, un antibiotique et/ou un agent stéroïdal anti-inflammatoire. Les implants biodégradables peuvent se présenter sous diverses formes, telles que des tiges, des pastilles, des billes, des bandes ou des micro-particules et peuvent être administrés dans un sinus dans divers supports acceptables sur le plan pharmaceutique.

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