C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2519161
This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds. The invention further relates to a method of modifying the acetylation status of a transcription factor binding site on histone or DNA by raising local concentrations of Sir2.
Guarente Leonard P.
Imai Shin-Ichiro
Vaziri Homayoun
Massachusetts Institute Of Technology
Smart & Biggar
Whitehead Institute For Biomedical Research
LandOfFree
Sir2 activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sir2 activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sir2 activity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1880661