A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/455 (2006.01)
Patent
CA 2531253
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screenning for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
L'invention concerne des composés qui inhibent un échange de base du gène SIR2 (<= silent information regulator 2 >=) bien plus quela déacétylation, ce qui permet d'améliorer l'activité de déacétylation de SIR2. Ladite invention a également pour objet des méthodes d'utilisation des composés d'amélioration de la déacétylation de SIR2 et d'accroissement de la longévité d'un organisme. Cette invention a aussi trait à des méthodes de criblage de composés qui améliorent l'activité de déacétylation de SIR2 et entraînent l'augmentation de la longévité d'un organisme.
Sauve Anthony A.
Schramm Vern L.
Albert Einstein College Of Medicine Of Yeshiva University
Osler Hoskin & Harcourt Llp
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