Sirna and methods of manufacture

Details Sirna and methods of manufacture Sirna and methods of manufacture

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2662959

Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA are also provided.

L'invention concerne de l'ARN à double brin d'environ 19 à environ 25 nucléotides de longueur, capable de réguler l'expression d'un gène par interférence d'ARN. Un tel ARN à double brin est particulièrement utile pour traiter une maladie ou des conditions associées à un ARNm cible ou un gène cible. Des procédés de fabrication et des procédés d'utilisation de l'ARN à double brin sont également fournis.

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