Sirna conjugate and preparation method thereof

Details Sirna conjugate and preparation method thereof Sirna conjugate and preparation method thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2761749

The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.

La présente invention concerne un conjugué siRNA-polymère, et son procédé de préparation et, plus spécifiquement, un conjugué hybride formé par liaison covalente de siRNA et d'un composé polymère en vue d'améliorer la biostabilité de siRNA, et un procédé de préparation du conjugué hybride. Le conjugué de la présente invention peut améliorer la biostabilité de siRNA, ce qui permet d'administrer de manière efficace siRNA en tant qu'agent thérapeutique dans des cellules et d'avoir l'activité de siRNA même avec une petites dose d'une concentration relativement faible. En conséquence, le conjugué peut être utilisé de manière avantageuse non seulement comme un outil de traitement avec siRNA pour les caun nouveau système d'administration de siRNA.

Affiliated with

Also associated with

Rating

Sirna conjugate and preparation method thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sirna conjugate and preparation method thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sirna conjugate and preparation method thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1876966