Sirna libraries optimized for predetermined protein families

Details Sirna libraries optimized for predetermined protein families Sirna libraries optimized for predetermined protein families

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2515688

siRNA Libraries Optimized for Predetermined Protein Families ABSTRACT Libraries for generating small inhibitory RNA (siRNA) are provided where the members of the library are optimized to inhibit the expression of genes that encode a predetermined family of proteins. The members of the library target at least mRNA encoding all members of the family of proteins. Methods for generating siRNA libraries of the present invention are also provided.

L'invention concerne des bibliothèques permettant de générer des petits AN interférence (Ainsi) dans lesquelles les éléments de la bibliothèque sont optimisés afin d'inhiber l'expression de gènes codant pour une famille de protéines prédéterminée. Les éléments de la bibliothèque ciblent au moins un ARNm codant pour tous les membres de la famille de protéines. L'invention concerne également des méthodes permettant de générer les bibliothèques d'ARNsi de l'invention.

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