A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/175 (2006.01) A61K 31/00 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2529510
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
L'invention concerne des méthodes et des composition modulant l'activité de membres de la famille des protéines du type sirtuine désacétylase ; l'activité de p53 ; la durée de vie et la sensibilité au stress de cellules et d'organismes. Des méthodes citées à titre d'exemple consistent à mettre un cellule en contact avec un composé d'activation, tel que le flavone, le stilbène, le flavanone, l'isoflavone, la catéchine, la chalcone, le tanin et l'anthocyanidine ; ou un composé d'inhibition, tel qu'un sphingolipide, comme par exemple la sphingosine.
Bitterman Kevin J.
Howitz Konrad T.
Lamming Dudley W.
Sinclair David A.
Zipkin Robert E.
Biomol International L.p.
President And Fellows Of Harvard College
Riches Mckenzie & Herbert Llp
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