A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/192 (2006.01)
Patent
CA 2738019
Provided herein are SIRT4 compositions and methods of use thereof. The invention provides functional information for use in the identification and design of compounds that modulate SIRT4 enzyme activity (e.g., inhibition of fatty acid oxidation, ADP ribosylation, and/or downregulation of glutamate dehydrogenase), and to the compounds identified by such methods and the research, diagnostic and therapeutic uses of such compounds.
La présente invention concerne des compositions de SIRT4 et des procédés dutilisation de celles-ci. Linvention produit des informations fonctionnelles pour utilisation dans lidentification et la conception de composés qui modulent lactivité enzymatique SIRT4 (par exemple, inhibition de loxydation des acides gras, ribosylation dADP, et/ou régulation à la baisse de la glutamate déshydrogénase), et les composés identifiés par de tels procédés et des utilisations en recherche, diagnostiques et thérapeutiques de tels composés.
Deboer Vincent
Haigis Marcia C.
President And Fellows Of Harvard College
Riches Mckenzie & Herbert Llp
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