Site-directed bone formation

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/08 (2006.01) A61F 2/02 (2006.01) A61L 27/00 (2006.01) A61L 27/36 (2006.01) A61L 27/50 (2006.01) C12M 1/22 (2006.01) C12M 3/00 (2006.01) C12M 3/04 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2227784

Osteoblasts are cultured on a surface having a topography adapted to promote or enhance formation of bone, thus directing bone formation at predictable and desired sites. In an assay for the effects of a drug on bone formation, osteoblasts are cultured in a groove approximately 350 microns wide and 200 microns deep. The bone formation surface can be provided on a culture plate or on a prosthetic implant or transplant.

Des ostéoblastes sont mis en culture sur une surface présentant une topographie adaptée pour faciliter ou stimuler la formation des os, cette formation osseuse pouvant être ainsi dirigée sur des sites prévisibles et désirés. Dans une étude visant à déterminer les effets d'un médicament sur la formation osseuse, des ostéoblastes sont mis en culture dans un sillon d'approximativement 350 microns de large et 250 microns de profondeur. La surface de la formation osseuse peut être créée sur une lame de culture ou sur un implant ou transplant prothétique.

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