Site-directed modification of factor ix

Details Site-directed modification of factor ix Site-directed modification of factor ix

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) A61P 7/04 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2721362

The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced cysteine sites. The modified Factor IX polypeptides may be conjugated to a biocompatible polymer. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.

L'invention concerne des polypeptides du facteur IX modifié, tels que des polypeptides du facteur IX dans lesquels un ou plusieurs sites cystéine ont été introduits. Les polypeptides du facteur IX modifié peuvent être conjugués avec un polymère biocompatible. L'invention concerne également des procédés pour produire des polypeptides du facteur IX modifié, et des méthodes pour utiliser lesdits polypeptides du facteur IX modifié, par exemple, pour traiter des patients souffrant d'hémophilie B.

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