C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 35/14 (2006.01) A61K 35/16 (2006.01) C07K 1/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2586379
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Cette invention concerne des mutéines du facteur VIII qui sont liées de manière covalente, sur un site prédéfini autre qu'un N-terminal amine, à un ou plusieurs polymères biocompatibles tels que le polyéthylène glycol. Les conjugués de mutéine maintiennent l'activité procoagulante du facteur FVIII et possèdent des propriétés pharmacocinétiques améliorées.
Barnett Thomas
Chen Jianmin
Mei Baisong
Murphy John E.
Pan Clark Q.
Bayer Healthcare Llc
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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